Rhamnus purshiana bark Cascara Sagrada bark

Rhamnus purshiana bark contains anthraquinones. Anthraquinone glycosides are poorly absorbed from the gastrointestinal tract but are cleaved by gut bacteria to produce aglycones (such as emodin) that are more readily absorbed and are responsible for the purgative properties of these preparations.

Glycograngulin, anthraquinone glycosides of emodin, emodinanthrone and aloe-emodin, anthracene derivatives. Emodin is a naturally occurring anthraquinone present in the roots and bark of numerous plants of the genus Rhamnus. Extracts from the roots, bark, and/or dried leaves of buckthorn, senna, cascara, aloe, frangula, and rhubarb have been used as laxatives since ancient times and currently are widely used in the preparation of herbal laxative preparations.

Rhamnus purshiana drug interaction
Anthranoid-containing plants including Cassia senna and Rhamnus purshiana and soluble fibers including guar gum and psyllium can decrease the absorption of drugs.

Rhamnus species
Rhamrus alpina L.
Rhamnus fallax boiss
Rhamnus frangula L. has glycosides of chrysophanoldianthrone and chrysophanolphys-ciondianthrone and glycosides of emodin and emodinanthrone.
Rhamnus purshiana DC.

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